anti-alzheimer and antioxidant activity of celastrus paniculatus seed

نویسندگان

alama badrul

department of pharmacy, atish dipankar university of science and technology, dhaka, bangladesh haque ekramul

department of pharmacy, brac university, dhaka, bangladesh

چکیده

the crude methanolic extract of the seeds of celastrus paniculatus along with its organic soluble fractions were tested for their possible antioxidant and anti-alzheirmer (ad) activity. the extracts showed prominent dpph free radical scavenging activity, inhibiting activity of authentic peroxynitrite (onoo-) and inhibition of total reactive oxygen species (ros) generation. in dpph radical scavenging assay, the etoac fraction showed the highest activity with a ic50 value of 25.92±1.02 µg/ml whereas aqueous fractions had no activity at all within the tested concentration. scavenging of the authentic onoo- system, all extract/fractions showed good activity and among them, etoac fraction had the highest activity with a ic50 value of 15.79±0.18 µg/ml. etoac fraction also showed significant (pp

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Anti-Alzheimer and Antioxidant Activity of Celastrus paniculatus Seed

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عنوان ژورنال:
iranian journal of pharmaceutical sciences

جلد ۷، شماره ۱، صفحات ۴۹-۵۶

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